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DeCS
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Descriptor English:
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Pre-B Cell Receptors
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Descriptor Spanish:
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Receptores de Células Precursoras de Linfocitos B
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Descriptor Portuguese:
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Receptores de Células Precursoras de Linfócitos B
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Synonyms English:
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Cell Receptor, Pre-B
Cell Receptors, Pre-B
Pre B Cell Receptor
Pre B Cell Receptors
Pre-B Cell Receptor
Receptor, Pre-B Cell
Receptors, Pre-B Cell
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Tree Number:
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D12.776.124.790.651.950.750
D12.776.377.715.548.950.750
D12.776.543.750.705.816.821.750
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Definition English:
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Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells. |
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History Note English:
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2008
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Allowable Qualifiers English:
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Record Number:
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52788
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Unique Identifier:
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D054420
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Occurrence in VHL:
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Similar:
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DeCS
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